Blinded Vs Unblinded Monitoring in Clinical Research

Most studies are double blinded meaning that the site does not know if the patient is taking an active study drug or a placebo. Unblinded studies are less prevalent in clinical research but typically involve an injection as well as unblinded staff. Such studies do not allow blinded staff to see the investigational product. Instead unblinded monitors are designated who will review IP accountability while blinded monitors focus on other aspects of the study during their monitoring visits.